August 6, 2025PLoS ONEOpen Access

Structure-based identification of bioactive compounds as trace amine-associated receptor 1 agonists for the therapeutic management of major depressive disorder

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Structure-based screening identifies potential taar1 agonists in phytochemicals, suggesting novel antidepressant options.

This research identifies bioactive compounds as taar1 agonists for managing major depressive disorder.
Two phytochemicals, Bianthraquinone and Peimisine, showed strong binding affinities with taar1 in molecular docking.
The study utilized a structure-based virtual screening approach involving Lipinski’s rule of five and pharmacokinetic evaluation.
Findings emphasize the therapeutic potential of natural taar1 agonists for reducing common side effects in depression treatments.

Elasbali et al. (2025) studied this question.

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