Bisphenol A as a Potential Modulator of Biochemical Markers in Children with Autism Spectrum Disorder

Autism spectrum disorder (ASD) is defined as a neurodevelopmental disorder characterized by repetitive behaviors, limited interests, and difficulties with social interactions. The purpose of this study was to measure the levels of bisphenol A (BPA), Vitamin D, thyroid-stimulating hormone (TSH), body mass index (BMI), and some hematological parameters in children with and without ASD. For this study, 75 boys between the ages of 3 and 10 years were split into two groups: 40 children with ASD (ASD group) and 35 children without ASD (control group). The results of the present study show that the level of BPA is significantly higher in the ASD group, also the mean value of BMI significantly increased in the ASD group compared with the control group. Regarding the Vitamin D and calcium levels, the findings illustrate that Vitamin D and calcium significantly decline in the ASD group compared to the control group. On the other hand, the variations in the serum TSH, magnesium, and hematological parameters were insignificantly changed, except that the level of white blood cell was significantly elevated in the ASD group. BPA is the main factor lowering Vitamin D and serum calcium levels, as well as raising inflammatory cells and BMI of autistic children (children with autism).