Review of the effectiveness of nuclear magnetic resonance spectroscopy for prostate cancer diagnosis

Prostate cancer (PCa) is the most common malignant neoplasm among men in Russia and one of the most common worldwide. PCa diagnosis, progression management, and evaluation of prognosis are performed using a combination of examinations: laboratory, instrumental, and various nomograms. The current methods of PCa diagnosis have limited sensitivity and specificity, therefore the search for new diagnostic methods is an important problem. Nuclear magnetic resonance (NMR) spectroscopy is a promising method allowing to detect malignant tumor-associated metabolites in biological liquids. According to some studies, PCa is associated with changes in levels of various metabolites in serum and plasma. This review presents the results of studies reporting on high effectiveness of NMR spectroscopy analysis of serum and plasma for PCa diagnosis.