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August 7, 2025Journal of Alzheimer s Disease

Immune system-associated genes in patients with Alzheimer's disease

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Authors

RYRui YaoZOZiyu OuyangTXTianyan Xu

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Overview

Genetic analysis links immune system genes to Alzheimer's disease risk in 1516 patients and 2010 controls, suggesting implicating pathways.

Key Points

  • Common variants in immune-related genes APOE and ABCA7 are significantly associated with Alzheimer's disease.
  • Two rare variants in the SAMD9 gene suggest a connection to Alzheimer's disease through immune pathways.
  • RNA-seq and molecular docking studies show the SAMD9 F222L variant affects immune-related gene expression.
  • Polygenic risk scores of immune-related genes correlate with various Alzheimer's disease biomarkers, emphasizing their importance.

Cite This Study

Yao et al. (2025) studied this question.

synapsesocial.com/papers/689522129f4f1c896c429a83https://doi.org/10.1177/13872877251364396
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