August 7, 2025

Molecular Insights into Prion Degradation in Creutzfeldt Jakob Disease’s Challenges and Future Directions: A Review

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Creutzfeldt-Jakob Disease is a fatal disorder marked by the accumulation of misfolded prion proteins in the brain.
Key proteolytic systems, like the ubiquitin-proteasome system, are vital for clearing toxic prion proteins effectively.
Recent advancements in diagnostic techniques, such as RT-QuIC, improve detection of prion disease in patients.
Future therapeutic strategies targeting lysosomal pathways hold promise for treating this currently untreatable disease.

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This review uncovers the roles of prion proteins and cellular pathways in Creutzfeldt-Jakob Disease, suggesting new therapeutic strategies ahead.

Jinde et al. (2025) studied this question.

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This review uncovers the roles of prion proteins and cellular pathways in Creutzfeldt-Jakob Disease, suggesting new therapeutic strategies ahead.