Case report highlights gingival metastasis in collision tumors involving colon adenocarcinoma and neuroendocrine carcinoma, suggesting a rare manifestation of colorectal cancer.
Collision tumors represent a relatively uncommon form of tumor manifestation, characterized by the independent coexistence of multiple distinct types of tumors. Large cell neuroendocrine carcinoma of the colorectum is a rare entity, with limited reports describing collision tumors involving adenocarcinoma and large cell neuroendocrine carcinoma. Distant metastases of colorectal cancer typically occur in sites such as bone, liver, and lungs; however, metastasis to the gingiva is rarely encountered. This paper reports a case of a collision tumor comprising colonic adenocarcinoma and large cell neuroendocrine carcinoma, with accompanying gingival metastasis.
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Zhang et al. (2025) studied this question.
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