Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 12, 2025Open Access

Deletion of the scavenger receptor Scarb1 in osteoblast progenitors and myeloid cells does not affect bone mass

View Full Paper
Ask AI
Bookmark
Share

Authors

MPMichela PalmieriTJTeenamol E. JosephHGHoracio Gomez‐Acevedo

Discussion

Loading...

Member takes

Overview

Deletion of scarb1 reveals no changes in bone mineral density in osteoblasts or myeloid cells, indicating that pc-oxpls do not affect bone mass via these pathways.

Key Points

  • SCARB1 deletion in osteoblast progenitors shows no change in bone mass, suggesting its limited role in bone metabolism.
  • Bone mineral density measurements in Scarb1 knockout mice indicate that PC-OxPLs do not exert adverse effects through osteoblasts.
  • Micro-CT analysis of cancellous and cortical bone in Scarb1 ΔLysM mice reveals no significant differences from controls.
  • Findings support the conclusion that PC-OxPLs' negative skeletal effects are not mediated by SCARB1 in the tested cell types.

Cite This Study

Palmieri et al. (2025) studied this question.

synapsesocial.com/papers/689a02afe6551bb0af8cbeeehttps://doi.org/10.1101/2025.07.09.663826
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease2016 · 554 citations
  2. 2IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice2005 · 71 citations
  3. 3Gender- and region-specific alterations in bone metabolism in Scarb1-null female mice2014 · 16 citations
  4. 4Scavenger receptor class B type I as a receptor for oxidized low density lipoprotein2001 · 167 citations
  5. 5Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual2012 · 250 citations