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July 13, 2025Open Access

Cell-Free DNA Reveals the Longitudinal Effects of Temozolomide Treatment and Host Co-Culture in Glioblastoma Models

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Authors

SMSharvari MankameHNHersh NandaMKMaria Kyriakidou

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Overview

Analysis reveals cfDNA dynamics and tumor burden tracking in glioblastoma during temozolomide treatment, indicating its potential as a liquid biopsy tool.

Key Points

  • Cell-free DNA serves as a promising biomarker to monitor glioblastoma progression and treatment response.
  • Increased cfDNA yield during temozolomide treatment points to its relevance in assessing therapy efficacy.
  • The co-culture system effectively differentiates contributions of glioblastoma and normal astrocyte cells to cfDNA.
  • Findings highlight the practical application of cfDNA in managing glioblastoma with non-invasive monitoring techniques.

Cite This Study

Mankame et al. (2025) studied this question.

synapsesocial.com/papers/689a02afe6551bb0af8cbf7bhttps://doi.org/10.1101/2025.07.12.662613
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