Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 13, 2025Open Access

Function-specific epistasis shapes evolutionary trajectories towards antibiotic resistance

View Full Paper
Ask AI
Bookmark
Share

Authors

GPGabriela PetrungaroTFTheresa FinkBFBooshini Fernando

Discussion

Loading...

Member takes

Overview

Experiments reveal that function-specific epistasis alters resistance trajectories in Escherichia coli, suggesting new treatment strategies.

Key Points

  • Evolution of antibiotic resistance is largely repeatable across genetic backgrounds.
  • Function-specific epistasis affects the trajectory of resistance evolution in Escherichia coli.
  • Robotic evolution experiments were used to analyze resistance to three clinically relevant antibiotics.
  • Disrupting certain cellular functions can slow down the evolution of resistance, offering treatment insights.

Cite This Study

Petrungaro et al. (2025) studied this question.

synapsesocial.com/papers/689a02afe6551bb0af8cbf88https://doi.org/10.1101/2025.07.09.663857
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Insect decline in the Anthropocene: Death by a thousand cuts2021 · 1,971 citations
  2. 2Massive overproduction of dihydrofolate reductase in bacteria as a response to the use of trimethoprim1987 · 103 citations
  3. 3Diminishing Returns From Beneficial Mutations and Pervasive Epistasis Shape the Fitness Landscape for Rifampicin Resistance in <i>Pseudomonas aeruginosa</i>2010 · 208 citations
  4. 4Experimental Tests of the Roles of Adaptation, Chance, and History in Evolution1995 · 523 citations