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July 14, 2025

Right Hemispheric Broca's Homologue Mediates Pain-Depression Loop: fNIRS Evidence of Language Network Remodeling in Comorbid Chronic Pain and Depression

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Authors

JZJiaren ZhengXiamen UniversityNZNing ZhuNingbo UniversityJHJiaxi HuangXiamen University

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Overview

This analysis identifies how chronic somatic pain affects the language network and depression in patients, suggesting new therapeutic pathways.

Key Points

  • Chronic somatic pain significantly suppresses the right hemispheric Broca's homologue, impacting language processing in depression.
  • Participants with chronic pain exhibited hypofunction in frontal brain areas during language tasks compared to controls.
  • The study utilized functional near-infrared spectroscopy to assess brain activity during verbal tasks in a large participant group.
  • Findings indicate that changes in the language network may serve as biomarkers for neuromodulation therapy in depression.

Cite This Study

Zheng et al. (2025) studied this question.

synapsesocial.com/papers/689a02afe6551bb0af8cc197https://doi.org/10.21203/rs.3.rs-6998159/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Right broca homologue mediates the pain-depression circuit: a case-control Functional Near-Infrared Spectroscopy (fNIRS) study on language network remodeling in chronic pain-depression comorbidity*2026
  2. 2Is chronic pain an affective disorder? Moderation of resting-state functional connectivity within the emotional brain by depressive symptoms2022 · 1 citations
  3. 3Common neural correlates of chronic pain – A systematic review and meta-analysis of resting-state fMRI studies2025 · 45 citations
  4. 4Neural Circuitry Remodeling in Chronic Pain and Depression Comorbidity: Toward an Emotion-Perception Integration Network Model2026 · 4 citations
  5. 5Relationship of prefrontal cortex activity with anhedonia and cognitive function in major depressive disorder: an fNIRS study2024 · 3 citations