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July 14, 2025

MRI investigation of orientation-dependent changes in microstructure and function in a mouse model of mild traumatic brain injury

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Authors

AEAmr EedJHJake HamiltonXXXiaoyun Xu

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Overview

Diffusion MRI reveals microstructural alterations in white matter of mice with mTBI, suggesting orientation impacts damage.

Key Points

  • Orientation of white matter tracts influences susceptibility to mild traumatic brain injury (mTBI).
  • Diffusivity and diffusional kurtosis metrics decreased in injured mice, indicating microstructural changes.
  • Functional MRI analysis highlighted deficits in connectivity between brain regions related to mTBI.
  • Females exhibited more significant microstructural changes than males following mTBI, as shown by diffusion MRI.

Cite This Study

Eed et al. (2025) studied this question.

synapsesocial.com/papers/689a02b6e6551bb0af8cc2b9https://doi.org/10.21203/rs.3.rs-6985478/v1
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