One-step alcohol phosphorylation method increases atom efficiency for phosphate monoester synthesis in alcohols, suggesting safer applications in pharmaceuticals.
Alcohol phosphorylation is a key reaction to synthesize phosphate monoester that is often found in biomolecules and pharmaceuticals. However, alcohol phosphorylation is usually performed under harsh reaction conditions, using hazardous reagents and ending up with low atom efficiency. Here, we develop a one-step alcohol phosphorylation methodology to synthesize phosphate monoester under ambient condition without the use of toxic oxidants that is powered by renewable energy. This atom-efficient reaction is specific towards aliphatic and benzylic alcohols instead of phenols and can be applicable toward straight-chain, branched, benzylic, aromatic, cyclic alcohols, and amino acids like serine and threonine. The utilization of renewable energy sources free of exogenous oxidants under ambient conditions offers a safer and more efficient approach for electrochemical synthesis of phosphate monoester for pharmaceutical applications.
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Cheung et al. (2025) studied this question.
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