July 14, 2025

Male mice lacking Magel2 in hypothalamic POMC neurons that innervate the medial amygdala exhibit increased stress-induced anxiety-like behavior and display reduced spatial reward learning.

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Male mice with magel2 deletion in hypothalamic pomc neurons exhibit increased anxiety under stress.
Behavioral tests revealed significant differences in anxiety-like behavior and spatial learning compared to controls.
The study explores how magel2 in medial amygdala-innervating neurons affects behavior related to prader-willi syndrome.
Findings may guide therapeutic strategies for mental health issues in individuals with prader-willi syndrome.

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Male mice lacking magel2 show increased stress-induced anxiety and reduced spatial learning, suggesting implications for Prader-Willi syndrome.

Lee et al. (2025) studied this question.

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Male mice lacking magel2 show increased stress-induced anxiety and reduced spatial learning, suggesting implications for Prader-Willi syndrome.