July 15, 2025

Supplementary Data S2 from Mechanism of Initial Favorable Response to Decitabine in TP53-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse

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Nanopore sequencing identifies mechanisms of response and relapse in TP53-mutated MDS/AML patients, suggesting targeted interventions.

Decitabine shows initial favorable responses in patients with TP53 mutations affecting MDS and AML.
Nanopore sequencing reveals specific genetic mechanisms contributing to relapse after initial treatment.
The study includes analysis of both patient response data and genetic sequencing of samples.
Identifying mechanisms of relapse can lead to improved treatment strategies for MDS and AML patients.
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Ng et al. (2025) studied this question.

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