July 15, 2025

Supplementary Data S5 from Mechanism of Initial Favorable Response to Decitabine in TP53-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse

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Discussion

Differential gene and GSEA analysis reveals key insights into Decitabine's effects in TP53-mutated MDS/AML.

Decitabine shows an initial favorable response in patients with TP53 mutations in MDS/AML.
Differential gene analysis and GSEA were used to assess the response mechanisms of Decitabine.
Single-cell RNA sequencing (scRNA-seq) provided detailed insights into cellular responses.
Understanding these mechanisms is crucial for improving treatment strategies and managing relapses in MDS/AML.

Ng et al. (2025) studied this question.

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