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July 15, 2025

Supplementary Material S1 from ⁶⁸Ga-NK224 PET/CT for Noninvasive Evaluation of PD-L1 Expression and Intertumor Heterogeneity: A Translational Exploratory Study

Liang Zhao Yizhen Pang Yi Ding Jianhao Chen Jianyang Fang Lingyu Yu Dan Ruan Yaqing Dai Hui Zhou Hao Fu Wei Guo Long Sun Hua Wu Shan Zhong Qin Lin Haojun Chen

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Key Points

The study explores using PET/CT imaging to evaluate PD-L1 expression in tumors.
Findings indicate a link between PD-L1 expression and intertumor heterogeneity in various cancers.
Methods included synthesizing NK224 and assessing its efficacy in imaging.
This approach could enhance personalized cancer treatment strategies by identifying PD-L1 levels.

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Implication

Exploratory study demonstrates PET/CT detects PD-L1 expression in cancers, suggesting its role in understanding tumor heterogeneity.

Abstract

Supplementary Material S1. Procedure of NK224 synthesis.

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Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc6d8 https://doi.org/10.1158/1078-0432.29568343

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S1 from <sup>68</sup>Ga-NK224 PET/CT for Noninvasive Evaluation of PD-L1 Expression and Intertumor Heterogeneity: A Translational Exploratory Study2025
2Supplementary Figure S3 from <sup>68</sup>Ga-NK224 PET/CT for Noninvasive Evaluation of PD-L1 Expression and Intertumor Heterogeneity: A Translational Exploratory Study2025
3Supplementary Figure S2 from <sup>68</sup>Ga-NK224 PET/CT for Noninvasive Evaluation of PD-L1 Expression and Intertumor Heterogeneity: A Translational Exploratory Study2025
4Supplementary Figure S4 from <sup>68</sup>Ga-NK224 PET/CT for Noninvasive Evaluation of PD-L1 Expression and Intertumor Heterogeneity: A Translational Exploratory Study2025
5Supplementary Figure S6 from <sup>68</sup>Ga-NK224 PET/CT for Noninvasive Evaluation of PD-L1 Expression and Intertumor Heterogeneity: A Translational Exploratory Study2025