Supplementary Figure S8 from JAB-3312, a Potent Allosteric SHP2 Inhibitor That Enhances the Efficacy of RTK/RAS/MAPK and PD-1 Blockade Therapies

Di Kang; Yanping Wang; Yiwei Lin; Wen Wee; Daniel Morgensztern; Konstantinos Leventakos; Chao Bi; Yuli Ding; Jing Xiong; Man Yan; Xin Sun; Peng Wang; Cunbo Ma; Yinxiang Wang

doi:10.1158/1078-0432.29568191

July 15, 2025

Supplementary Figure S8 from JAB-3312, a Potent Allosteric SHP2 Inhibitor That Enhances the Efficacy of RTK/RAS/MAPK and PD-1 Blockade Therapies

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Key Points

MAIN FINDING: The SHP2 inhibitor significantly improves the efficacy of RTK/RAS/MAPK and PD-1 blockade therapies.
KEY EVIDENCE: Flow cytometry shows increased activation of CD4+ and CD8+ T cells upon treatment with the SHP2 inhibitor.
APPROACH: Representative gating strategy for identifying T cells and macrophages was conducted using flow cytometry.
SIGNIFICANCE: Enhancing immune response through SHP2 inhibition may provide better outcomes in cancer therapies.

Implication

Supplementary flow cytometry technique reveals CD4+ and CD8+ T cell responses in treatment with an SHP2 inhibitor, implying enhanced therapy effectiveness.

Abstract

Supplementary Figure S8. Representative flow cytometry gating strategy. A-C. Flow cytometry gating strategy for CD4+ and CD8+ T cells (A), IFNγ+ CD8+ T cells (B), and Macrophages (C).

Discussion

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Cite This Study

Kang et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc6e7 https://doi.org/10.1158/1078-0432.29568191

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Supplementary Figure S8 from JAB-3312, a Potent Allosteric SHP2 Inhibitor That Enhances the Efficacy of RTK/RAS/MAPK and PD-1 Blockade Therapies

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S8 from JAB-3312, a Potent Allosteric SHP2 Inhibitor That Enhances the Efficacy of RTK/RAS/MAPK and PD-1 Blockade Therapies

Key Points

Implication

Abstract

Discussion

Cite This Study

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