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July 15, 2025International Journal of Molecular SciencesOpen Access

Melatonin as the Missing Link Between Sleep Deprivation and Immune Dysregulation: A Narrative Review

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Authors

ISIda SzataniakKPKacper Packi

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Overview

Narrative review analyzes melatonin's impact on immune function in sleep-deprived individuals, indicating potential therapeutic benefits.

Key Points

  • Melatonin acts as a key mediator in immune function affected by sleep deprivation.
  • Reduced melatonin levels correlate with higher proinflammatory cytokines and lower immune cell activity.
  • The review highlights melatonin's dual role in regulating immune pathways and mitochondrial health.
  • Promoting healthy sleep and melatonin supplementation may help restore immune balance, especially in vulnerable populations.

Cite This Study

Szataniak et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc789https://doi.org/10.3390/ijms26146731
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