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July 15, 2025Clinical Microbiology Reviews

Lessons learned from successful implementation of tetanus and diphtheria vaccination programs

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Authors

MSMark K. SlifkaOregon National Primate Research CenterATArchana ThomasOregon National Primate Research CenterLGLina GaoHenan Academy of Agricultural Sciences

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Overview

Evidence-based review contrasts tetanus and diphtheria vaccines with childhood vaccinations, suggesting changes to booster protocols.

Key Points

  • Tetanus and diphtheria vaccines have led to remarkably low disease incidence rates in the U.S.
  • Decennial adult booster vaccinations may not be necessary for maintaining immunity in the general population.
  • Updating vaccination protocols could align U.S. guidelines with WHO recommendations, enhancing public health.
  • Proposed changes to boosters could save up to $1 billion annually in healthcare costs.

Cite This Study

Slifka et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc856https://doi.org/10.1128/cmr.00031-25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Duration of Humoral Immunity to Common Viral and Vaccine Antigens2007 · 1,358 citations
  2. 2National public health response to an outbreak of toxigenic Corynebacterium diphtheriae among asylum seekers in England, 2022: a descriptive epidemiological study2023 · 20 citations
  3. 3Best vaccination practice and medically attended injection site events following deltoid intramuscular injection2015 · 68 citations
  4. 4Diphtheria in the United Kingdom, 1986–2008: the increasing role of<i>Corynebacterium ulcerans</i>2010 · 169 citations
  5. 5A Population-Based Serologic Survey of Immunity to Tetanus in the United States1995 · 354 citations