Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
July 15, 2025

Pde10a gates light responses in the SCN to regulate circadian photoentrainment

View Full Paper
Ask AI
Bookmark
Share

Authors

RKRuchi KomalMTMichael B ThomsenHWHui Wang

Discussion

Loading...

Member takes

Overview

Transcriptome analysis reveals Pde10a's role in regulating light responsiveness in the suprachiasmatic nucleus, indicating its importance in circadian rhythms.

Key Points

  • The study identifies Pde10a as essential for regulating SCN responsiveness to light during the daytime.
  • Transcriptomic analysis classified 10 distinct neuronal subtypes within the suprachiasmatic nucleus of mice.
  • Significant light-induced transcriptomic changes were observed during the behavioral dead zone, challenging previous notions.
  • This research advances understanding of how circadian rhythms are synced with light, potentially impacting sleep regulation.

Cite This Study

Komal et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc901https://doi.org/10.1101/2025.07.14.664763
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phase Shifting Capacity of the Circadian Pacemaker Determined by the SCN Neuronal Network Organization2009 · 104 citations
  2. 2Wavelet-Based Time Series Analysis of Circadian Rhythms2011 · 97 citations
  3. 3Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons2002 · 64 citations
  4. 4Multiple regulatory elements result in regional specificity in circadian rhythms of neuropeptide expression in mouse SCN1999 · 91 citations
  5. 5Light Has Diverse Spatiotemporal Molecular Changes in the Mouse Suprachiasmatic Nucleus2020 · 16 citations