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June 27, 2026Cellular and Molecular Life SciencesOpen Access

Divergent molecular and circuit mechanisms underlie light entrainment of retinal and suprachiasmatic nucleus circadian clocks

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Authors

AJA JandotHCH CalligaroADA Dianak-Shoori

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Overview

Randomized trial examines light effects on retinal and SCN clocks, suggesting distinct mechanisms for timekeeping.

Key Points

  • The aim is to understand how different photoreceptor pathways affect photic entrainment in retinal and SCN circadian clocks.
  • Conducted transcriptomic analysis of retinal and SCN responses to 530 nm monochromatic light in mouse models with specific photoreceptor deletions.
  • Analyzed light-responsive transcriptional signatures under photopic conditions across various genotypes.
  • Investigated rod/cone electrical coupling and its role in light-induced phase resetting of the retinal clock.
  • Identified distinct light-responsive transcriptional signatures in retinal and SCN tissues, with shared rod-driven immediate early-genes.
  • Light did not shift the SCN clock phase but had a robust phase-shifting effect on the retinal clock.
  • OFF-cone bipolar cell circuit was found to be both necessary and sufficient for mediating light-induced phase resetting of the retinal clock.

Cite This Study

Jandot et al. (2026) studied this question.

synapsesocial.com/papers/6a3f67aaaea7db3c1953efc9https://doi.org/10.1007/s00018-026-06298-8
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