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July 16, 2025Journal of Clinical MedicineOpen Access

Beyond Standard Shocks: A Critical Review of Alternative Defibrillation Strategies in Refractory Ventricular Fibrillation

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Authors

BPBenedetta PernaMGMatteo GuarinoRFRoberto De Fazio

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Overview

Narrative review highlights survival benefits of alternative defibrillation strategies in refractory ventricular fibrillation, indicating challenges in clinical application.

Key Points

  • Alternative defibrillation strategies aim to improve outcomes in patients with refractory ventricular fibrillation.
  • Dual sequential external defibrillation showed higher rates of return of spontaneous circulation compared to standard defibrillation.
  • The analysis included studies from multiple databases, primarily retrospective studies and one randomized controlled trial.
  • Identifying effective strategies for RVF management is critical due to current poor survival rates and implementation barriers.

Cite This Study

Perna et al. (2025) studied this question.

synapsesocial.com/papers/689a02c3e6551bb0af8cc9bbhttps://doi.org/10.3390/jcm14145016
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Alternative Defibrillation Strategies for Refractory Ventricular Fibrillation: A Systematic Review and Meta-Analysis2023
  2. 2Enhancing Patient Safety in Refractory Ventricular Fibrillation: A Systematic Review of Double Sequential and Vector Change Defibrillation Barriers2025 · 1 citations
  3. 3Defibrillation in refractory cardiac arrest: knowledge gaps and future priorities2026
  4. 4A new defibrillation strategy for refractory ventricular fibrillation during out-of-hospital cardiac arrest: are two better than one?2023 · 3 citations
  5. 5The impact of alternate defibrillation strategies on shock-refractory and recurrent ventricular fibrillation: A secondary analysis of the DOSE VF cluster randomized controlled trial2024 · 49 citations