July 16, 2025

Dysregulated microRNA expression in neonatal sepsis: validation study of potential novel biomarkers

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Validation study identifies dysregulated microRNAs as potential biomarkers for neonatal sepsis severity in infants.

Dysregulation of miR-15a and miR-223 was significant in infants with neonatal sepsis, making them potential biomarkers.
Among 64 newborns, 19 cases were early-onset and 45 were late-onset sepsis, with positive blood cultures in 45%.
Statistical analysis indicated miR-15a showed a notable decrease in expression after 7 days, correlating with sepsis severity.
This work emphasizes the role of microRNAs as diagnostic tools that could enhance treatment for neonatal sepsis patients.

Jouza et al. (2025) studied this question.

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