July 16, 2025BiomedicinesOpen Access

Targeting Cellular Senescence: Pathophysiology in Multisystem Age-Related Diseases

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Authors

JLJinxue LiuJiangmen Central Hospital HYHongliang YuJilin University YXYuanyuan XuJiaxing University

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Implication

This review highlights cellular senescence's role in age-related diseases, suggesting targeted interventions like senolytic drugs may improve outcomes.

Key Points

Cellular senescence is a key driver of age-related diseases such as cardiovascular, neurodegenerative, and musculoskeletal disorders.
Senescence leads to irreversible cell cycle arrest and the release of inflammatory factors, disrupting tissue homeostasis.
Interventions like senolytic drugs and regular exercise may help target cellular senescence and improve health outcomes.
Understanding the mechanisms of cellular senescence is crucial for developing effective precision medicine strategies for aging populations.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/689a02c3e6551bb0af8cca2f https://doi.org/10.3390/biomedicines13071727

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Implication

This review highlights cellular senescence's role in age-related diseases, suggesting targeted interventions like senolytic drugs may improve outcomes.

Targeting Cellular Senescence: Pathophysiology in Multisystem Age-Related Diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

Targeting Cellular Senescence: Pathophysiology in Multisystem Age-Related Diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

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