July 16, 2025Open Access

An immunobiliary single-cell atlas resolves crosstalk of type 2 cDCs and γδT cells in cholangitis

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A disease trajectory of cDC2B was linked to Il17-inducing genes during cholangitis.
cDC2B maturation and homing were analyzed using single-cell RNA-sequencing methods.
γδT cells were primarily responsible for Il17 production, with distinct subtypes observed.
Il17 deficiency lessened liver fibrosis, establishing a connection between cDC2B and γδT cells in disease.

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Single-cell RNA-sequencing identifies crosstalk of cDC2 and γδT cells in cholangitis, suggesting new disease insights.

Thomann et al. (2025) studied this question.

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