Literature review identifies pathophysiological aspects of insulin resistance in gestational diabetes mellitus, suggesting implications for management.
Gestational diabetes mellitus (GDM) is a significant metabolic disorder characterized by impaired insulin sensitivity during pregnancy. This review explores the key pathophysiological mechanisms of insulin resistance in GDM, including dysfunction of insulin signaling pathways (IRS/PI3K/Akt), activation of inflammatory cascades (JNK, SOCS), and the role of adipokines (leptin, adiponectin, resistin). Hormonal factors such as placental lactogen, estrogens, progesterone, and thyroid hormones, which influence metabolic homeostasis and contribute to insulin resistance, are also discussed. Special attention is given to the link between adipokine imbalances, impaired lipolysis, elevated free fatty acids, and microangiopathy. The heterogeneity of GDM and its increasing burden necessitate further research to enhance understanding and management.
No takes yet. Share an insight, caveat, or question.
Хара et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: