What question did this study set out to answer?

To provide an updated overview of the physiological, environmental, and genetic determinants driving maternal insulin resistance during pregnancy and evaluate their clinical consequences.

November 19, 2019Journal of Diabetes ResearchOpen Access

Determinants of Maternal Insulin Resistance during Pregnancy: An Updated Overview

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Authors

UKUlla KampmannSteno Diabetes Centers SKSine KnorrSteno Diabetes Centers JFJens FuglsangSteno Diabetes Centers

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Implication

Review reveals multifactorial drivers of insulin resistance in pregnant women, highlighting targets to prevent maternal and fetal metabolic dysfunction.

Key Points

To provide an updated overview of the physiological, environmental, and genetic determinants driving maternal insulin resistance during pregnancy and evaluate their clinical consequences.
Literature review summarizing mechanistic evidence and clinical factors associated with insulin sensitivity changes across gestation.
Evaluation of hormonal, lifestyle, genetic, and epigenetic contributors affecting mothers with normal pregnancies, gestational diabetes, and type 2 diabetes.
Insulin resistance rises substantially during the second half of gestation, driven by an interplay of placental hormone secretion, maternal adiposity, physical inactivity, and genetic predispositions.
Severe insulin resistance develops predominantly in pregnancies complicated by gestational or pre-existing type 2 diabetes.
Uncontrolled maternal insulin resistance contributes directly to short- and long-term metabolic dysfunction in both the mother and the developing fetus.

Cite This Study

Kampmann et al. (2019) studied this question.

synapsesocial.com/papers/69dd4d3bcaee84831440c608 https://doi.org/10.1155/2019/5320156

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Implication

Review reveals multifactorial drivers of insulin resistance in pregnant women, highlighting targets to prevent maternal and fetal metabolic dysfunction.

Determinants of Maternal Insulin Resistance during Pregnancy: An Updated Overview

Discussion

Member takes

Implication

Key Points

Cite This Study

Determinants of Maternal Insulin Resistance during Pregnancy: An Updated Overview

Discussion

Member takes

Implication

Key Points

Cite This Study

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