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July 18, 2025npj ImagingOpen Access

Label-free and fluorescence imaging of oligodendrocytes and myelin

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Authors

YKYasmine KamenMDMegan DotyMCMatthew E Ciolkowski

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Overview

This protocol demonstrates label-free and fluorescence imaging of oligodendrocytes and myelin, suggesting new insights into myelin plasticity in the adult brain.

Key Points

  • Myelination is crucial for action potential conduction and precise timing in neural circuits.
  • Label-free optical imaging allows specific detection of compact myelin in living mice and tissues.
  • Fluorescence reporters and small molecule dyes enhance imaging resolution for oligodendrocytes.
  • These methods can help explore key questions about myelin maintenance, repair, and development.

Cite This Study

Kamen et al. (2025) studied this question.

synapsesocial.com/papers/689a02c9e6551bb0af8cce53https://doi.org/10.1038/s44303-025-00098-8
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