This review highlights how nkp30 mediates nk cell activation and its roles in antitumor and anti-infection, suggesting new therapeutic avenues.
Natural killer cells (NK) are crucial components of the immune system. NKp30, a significant activation receptor on the NK cell membrane, plays a cytotoxic role by recognizing and binding to corresponding ligands. This interaction mediates the activation of NK cells and the release of regulatory factors, participating in antitumor and anti-infection processes. This review systematically summarizes the structural features and basic functions of NKp30, the impact of N-terminal glycosylation on NKp30 function, related NKp30 ligands and their roles, as well as the antitumor and anti-infective functions and mechanisms of NKp30. The aim is to provide a new perspective for a comprehensive understanding of NKp30 function.
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Shao et al. (2025) studied this question.
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