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July 19, 2025

Current Status of In Vitro Oocyte Growth and Development in Mammals.

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Authors

YHYuji Hirao

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Overview

Review analyzes in vitro oocyte development and culture systems, highlighting their implications for fertility treatments.

Key Points

  • Current in vitro methods have yet to make oocytes practical for widespread use in livestock production.
  • Mouse oocytes are the only type to achieve full developmental competence through in vitro methods to date.
  • Some bovine oocytes from early antral follicles produced viable offspring after in vitro culture for two weeks.
  • Maintaining follicle viability in culture systems for the initial growth period of 4-5 weeks remains a significant challenge.

Cite This Study

Yuji Hirao (2025) studied this question.

synapsesocial.com/papers/689a02c9e6551bb0af8ccf79https://doi.org/10.1002/rmb2.12669
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Follicular factors determining the developmental competence of porcine oocyte2019 · 5 citations
  2. 2Human cumulus-enclosed germinal vesicle oocytes from early antral follicles reveal heterogeneous cellular and molecular features associated with in vitro maturation capacity2015 · 85 citations
  3. 3Reversing complete mechanical transzonal projections disruption during mouse in vitro follicle culture with unaltered oocyte competence2021 · 19 citations
  4. 4Effects of long-term in vitro exposure to phosphodiesterase type-3 inhibitors on follicle and oocyte development2005 · 31 citations
  5. 5Initial steps in reconstruction of the human ovary: survival of pre-antral stage follicles in a decellularized human ovarian scaffold2019 · 147 citations