July 21, 2025

A novel cost-benefit decision-making task involving cued punishment; effects of sex and psychostimulant administration

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Novel task reveals altered decision-making in male and female rats following amphetamine and cocaine, highlighting sex differences.

Decision-making is influenced by cues predictive of punishment, affecting choice behavior in rats.
Male and female Long-Evans rats showed differing sensitivities to cues, impacting their reward preferences.
Acute amphetamine diminished the preference for large rewards associated with punishment cues across all groups.
These findings underscore how sex differences affect cognitive processes related to substance use.

Faraji et al. (2025) studied this question.

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