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July 21, 2025Open Access

Hyaluronic Acid in Liver Fibrosis: Role in Inflammation, Tissue Remodeling, and Disease Progression

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Authors

CRCarlos Rojano-AlfonsoCLCristina López‐VicarioBRBerta Romero-Grimaldo

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Overview

This review highlights the role of hyaluronic acid in liver inflammation and remodeling, suggesting therapeutic strategies for chronic liver diseases.

Key Points

  • Hyaluronic acid is crucial for maintaining liver architecture and regulating cell interactions.
  • Low-molecular-weight hyaluronic acid accumulation is linked to liver fibrosis and immune dysregulation.
  • The review discusses hyaluronic acid's dual role in tumor progression and its potential as a therapeutic target.
  • Strategies like blocking hyaluronic acid synthesis and receptors may alleviate HA-related liver damage.

Cite This Study

Rojano-Alfonso et al. (2025) studied this question.

synapsesocial.com/papers/689a060ee6551bb0af8cd0b8https://doi.org/10.20944/preprints202507.1470.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hyaluronic Acid in Liver Fibrosis: Role in Inflammation, Tissue Remodeling, and Disease Progression2025
  2. 2MASP1‑METTL3‑HAS2 axis aggravates liver fibrosis through HMW‑HA‑mediated senescence inhibition and LMW‑HA‑induced activation of hepatic stellate cells2026
  3. 3Development of a Liver Fibrosis Treatment Targeting Inhibition of Hepatic Stellate Cell Activation2026
  4. 4Recent advances in exploring the properties and applications of hyaluronan2024 · 2 citations
  5. 5Liver Sinusoidal Endothelial Cells and Their Regulation of Immunology, Collagenization, and Bioreactivity in Fatty Liver: A Narrative Review2025 · 7 citations