July 21, 2025Open Access

Barcoded Rabies In Situ Connectomics for high-throughput reconstruction of neural circuits

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Connectomics technique maps synaptic connectivity in mouse brain, revealing unique input patterns in neurons.

MAIN FINDING: BRISC maps synaptic inputs of hundreds of neurons in the mouse primary visual cortex.
KEY EVIDENCE: Identified 7,814 putative synaptic connections across 385 neurons using barcoded rabies.
APPROACH: Developed a library of diverse rabies viruses for unique labeling and controlled the density of starter neurons.
SIGNIFICANCE: Advances the understanding of neural circuits by enabling connectivity mapping at large scales.

Becalick et al. (2025) studied this question.

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July 21, 2025Open Access

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Authors

Connectomics technique maps synaptic connectivity in mouse brain, revealing unique input patterns in neurons.

MAIN FINDING: BRISC maps synaptic inputs of hundreds of neurons in the mouse primary visual cortex.
KEY EVIDENCE: Identified 7,814 putative synaptic connections across 385 neurons using barcoded rabies.
APPROACH: Developed a library of diverse rabies viruses for unique labeling and controlled the density of starter neurons.
SIGNIFICANCE: Advances the understanding of neural circuits by enabling connectivity mapping at large scales.

Becalick et al. (2025) studied this question.

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