July 21, 2025Open Access

Pervasive noise in human splice site selection

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Ultra-deep sequencing unveils pervasive low-fidelity splice sites in human RNA, suggesting the role of noise in splicing decisions.

Main finding shows abundant cryptic splicing events linked to genomic features enhancing splicing noise.
Key evidence indicates widespread use of low-fidelity splice sites tied to the recruitment of the spliceosome.
Approach involved ultra-deep sequencing to monitor splicing intermediates in human RNA compartments.
Significance lies in revealing how biological noise contributes to transcriptome diversity and splicing errors.

Khokhar et al. (2025) studied this question.

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