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July 21, 2025CellsOpen Access

HDACs and Their Inhibitors on Post-Translational Modifications: The Regulation of Cardiovascular Disease

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Authors

SYSiyi YangYSYiyun SunWYWei Yu

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Overview

Reviews mechanisms of HDACs and HDAC inhibitors on post-translational modifications linked to cardiovascular diseases, suggesting novel treatment pathways.

Key Points

  • Cardiovascular diseases, including heart failure and atherosclerosis, pose serious global health risks.
  • Post-translational modifications play a crucial role in protein function and cardiovascular health.
  • HDACs are involved in modifying gene expression and are linked to cardiovascular disease progression.
  • HDAC inhibitors may offer a new treatment strategy by impacting post-translational modifications in cardiovascular diseases.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/689a060ee6551bb0af8cd2aahttps://doi.org/10.3390/cells14141116
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Also Consider

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  1. 1Unlocking cardiac health: exploring the role of class I HDACs in cardiovascular diseases2025
  2. 2Histone Modifications in Cardiovascular Disease: Mechanisms and Therapeutic Opportunities2026 · 1 citations
  3. 3Histone deacetylase 4: A therapeutic target for cardiovascular diseases (Review)2025 · 2 citations
  4. 4Targeting histone deacetylases for heart failure2009 · 42 citations
  5. 5Role of histone post-translational modifications in atherosclerosis and the therapeutic potential of targeting epigenetic modifiers2025