Whole-cell biocatalyst reduces carboxylic acids to alcohols using hydrogen, indicating safer, non-explosive processes.
The reduction of carboxylic acids to alcohols is a key chemical transformation. We present a whole-cell biocatalyst employing carboxylic acid reductases and H2 for cofactor regeneration. H2 as a reductant ensures high atom economy, enabling a more sustainable route to alcohols. Notably, we showcase that the reaction proceeds under oxygen-limited conditions, demonstrating potential for safer, non-explosive bioprocesses.
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Karava et al. (2025) studied this question.
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