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September 10, 2025Nature CommunicationsOpen Access

Electroreductive amination of carboxylic acids by cobalt catalysis

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Authors

HBHuihua BiZCZhizheng ChenCBChong−Wen Bi

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Overview

Electrocatalytic hydrogenation produces complex alkylamines from carboxylic acids and amines, suggesting practical applications in organic synthesis.

Key Points

  • This method achieves the conversion of carboxylic acids into alkylamines under mild conditions.
  • Using a cobalt complex as a catalyst facilitates a safer process without flammable hydrogen gas.
  • The technique is versatile, enabling the synthesis of structurally diverse alkylamines from various substrates.
  • This approach can assist in isotope labeling through readily available deuterium sources.

Cite This Study

Bi et al. (2025) studied this question.

synapsesocial.com/papers/68c1b19354b1d3bfb60e8b3fhttps://doi.org/10.1038/s41467-025-62396-4
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