What question did this study set out to answer?

This research aims to explore an efficient method to couple thioamides with olefins using cobalt catalysis.

Electrohydrogenative Coupling of Thioamides with Olefins by Cobalt Catalysis

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Randomized trial demonstrates effective synthesis of α-branched amines from thioamides and olefins, suggesting a sustainable approach.

This research aims to explore an efficient method to couple thioamides with olefins using cobalt catalysis.
Utilized an earth-abundant cobalt complex as an electrocatalyst for the hydrogenative coupling process.
Synthesized over 60 α-branched amines and 12 deuterated analogues under mild electrochemical conditions.
Mechanistic studies were conducted to identify key intermediates such as imines and α-amino radicals.
Successfully synthesized more than 60 α-branched amines, indicating high selectivity and efficiency.
Functional groups like aryl halides and esters were tolerated, showing broad applicability of the method.
Late-stage modification of complex molecules was achieved, highlighting versatility.

Jiang et al. (2026) studied this question.

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View Full Paper

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Authors

Randomized trial demonstrates effective synthesis of α-branched amines from thioamides and olefins, suggesting a sustainable approach.

This research aims to explore an efficient method to couple thioamides with olefins using cobalt catalysis.
Utilized an earth-abundant cobalt complex as an electrocatalyst for the hydrogenative coupling process.
Synthesized over 60 α-branched amines and 12 deuterated analogues under mild electrochemical conditions.
Mechanistic studies were conducted to identify key intermediates such as imines and α-amino radicals.
Successfully synthesized more than 60 α-branched amines, indicating high selectivity and efficiency.
Functional groups like aryl halides and esters were tolerated, showing broad applicability of the method.
Late-stage modification of complex molecules was achieved, highlighting versatility.

Jiang et al. (2026) studied this question.

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