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September 10, 2025Organic Chemistry Frontiers

Catalyst-Free Reductive Desulfurization of Thioamides with Ammonia Borane through Concerted Double-hydrogen Transfer Mechanism

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Authors

WLWeikang LiZCZhe ChenCXChenhan Xiong

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Overview

Catalyst-free approach achieved selective C=S and C-N cleavage in thioamides, indicating new transformation potential.

Key Points

  • The method enables selective cleavage of C=S and C-N bonds in thioamides without catalysts, addressing existing limitations.
  • Selective transformations were achieved through a concerted double-hydrogen transfer mechanism, demonstrating notable efficacy.
  • This innovative method employed ammonia borane, significantly broadening the scope of reductive desulfurization reactions.
  • The approach highlights potential applications in green chemistry, aiming to improve sustainability in chemical processes.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c1c9d254b1d3bfb60f2dc5https://doi.org/10.1039/d5qo01028d
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Also Consider

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  1. 1Water‐Assisted Fe(CO) <sub>5</sub> Catalyzed Transfer Hydrodesulfurization of Thioamides2026
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  3. 3Additive- and catalyst-free deoxygenative reduction of amides and imides to amines with ammonia borane2025
  4. 4Titanium-Mediated Deoxygenation of Sulfoxides into Sulfides with Ammonia Borane under Mild Conditions2026
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