Catalyst-Free Reductive Desulfurization of Thioamides with Ammonia Borane through Concerted Double-hydrogen Transfer Mechanism

Weikang Li; Zhe Chen; Chenhan Xiong; Zhenjie Yang; Ning Wang; Peifeng Su; Yaru Jing; Haihua Huang; Zhuofeng Ke

doi:10.1039/d5qo01028d

January 1, 2025Organic Chemistry Frontiers

Catalyst-Free Reductive Desulfurization of Thioamides with Ammonia Borane through Concerted Double-hydrogen Transfer Mechanism

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Key Points

The method enables selective cleavage of C=S and C-N bonds in thioamides without catalysts, addressing existing limitations.
Selective transformations were achieved through a concerted double-hydrogen transfer mechanism, demonstrating notable efficacy.
This innovative method employed ammonia borane, significantly broadening the scope of reductive desulfurization reactions.
The approach highlights potential applications in green chemistry, aiming to improve sustainability in chemical processes.

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Implication

Catalyst-free approach achieved selective C=S and C-N cleavage in thioamides, indicating new transformation potential.

Abstract

The green reductive transformation of thioamides is highly desired yet faces challenges in broad substrate scope and selectivity for C=S and C-N cleavage. Existing catalytic hydrogenation methods are still limited...

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Li et al. (2025) studied this question.

synapsesocial.com/papers/68c1c9d254b1d3bfb60f2dc5 https://doi.org/10.1039/d5qo01028d

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Catalyst-Free Reductive Desulfurization of Thioamides with Ammonia Borane through Concerted Double-hydrogen Transfer Mechanism

Key Points

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Implication

Abstract

Discussion

Cite This Study

Catalyst-Free Reductive Desulfurization of Thioamides with Ammonia Borane through Concerted Double-hydrogen Transfer Mechanism

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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