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September 20, 2025Synlett

Additive- and catalyst-free deoxygenative reduction of amides and imides to amines with ammonia borane

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Authors

KXKe XuMZMin‐Jie ZhouXLXinrui Liu

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Overview

This additive-free technique reduces amides and imides to amines using ammonia borane, pointing to practical applications in synthetic chemistry.

Key Points

  • This method effectively reduces amides and imides to amines without the need for catalysts or additives.
  • Using ammonia borane as a mild reductant, the process successfully operates in open air, enhancing practicality.
  • The reduction technique accommodates tertiary, secondary, and primary amides, as well as more challenging imides.
  • This approach simplifies the synthetic process in organic chemistry, potentially broadening its applications.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68d46aa631b076d99fa67552https://doi.org/10.1055/a-2705-8871
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  1. 1Selective Deoxygenative Electroreduction of Amides2026 · 3 citations
  2. 2Catalyst- and Additive-Free Reduction of Carboxylic Acids and Amides Using Ammonia Borane as Hydrogen Source2025 · 1 citations
  3. 3Transfer Hydrogenation of Organic Azides to Amines by Ammonia Borane Complex Under Mild Conditions Catalyzed by Reusable Au Nanoparticles2026
  4. 4Catalyst- and Stoichiometry-Dependent Deoxygenative Reduction of Esters to Ethers or Alcohols with Borane–Ammonia2023 · 27 citations
  5. 5Catalytic Selective Deoxygenation and Deamination of Amides to Access Alkenes2026