What question did this study set out to answer?

To develop a protocol for the chemoselective reduction of organic azides to amines using ammonia borane and gold catalysts.

March 10, 2026European Journal of Organic ChemistryOpen Access

Transfer Hydrogenation of Organic Azides to Amines by Ammonia Borane Complex Under Mild Conditions Catalyzed by Reusable Au Nanoparticles

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Authors

EZElisavet‐Maria Zantioti‐ChatzoudaUniversity of Crete DMDimitra MalliotakiUniversity of Crete IZIoannis ZachilasUniversity of Crete

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Implication

This protocol demonstrates the effective conversion of azides to amines in the presence of gold nanoparticles, suggesting a new approach for selective reductions.

Key Points

To develop a protocol for the chemoselective reduction of organic azides to amines using ammonia borane and gold catalysts.
Utilized ammonia borane complex as reducing agent.
Employed gold nanoparticles supported on TiO2 as the catalyst at 0.5 mol%.
Conducted reactions at room temperature in protic solvents like ethanol or methanol.
Monitored the reduction of azides versus coexisting nitro groups.
Organic azides were reduced to amines within 15-30 minutes.
The reaction selectively targets the azide functionality, leaving other groups intact.
The catalyst was shown to be recyclable for at least three consecutive uses.

Cite This Study

Zantioti‐Chatzouda et al. (2026) studied this question.

synapsesocial.com/papers/69af953870916d39fea4c9d0 https://doi.org/10.1002/ejoc.202501198

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Implication

This protocol demonstrates the effective conversion of azides to amines in the presence of gold nanoparticles, suggesting a new approach for selective reductions.

Transfer Hydrogenation of Organic Azides to Amines by Ammonia Borane Complex Under Mild Conditions Catalyzed by Reusable Au Nanoparticles

Discussion

Member takes

Implication

Key Points

Cite This Study

Transfer Hydrogenation of Organic Azides to Amines by Ammonia Borane Complex Under Mild Conditions Catalyzed by Reusable Au Nanoparticles

Discussion

Member takes

Implication

Key Points

Cite This Study

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