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May 21, 2026Angewandte Chemie

Catalytic Selective Deoxygenation and Deamination of Amides to Access Alkenes

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Authors

QSQiu ShiWLWenbo H. Liu

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Overview

Randomized trial demonstrates efficient conversion of amides to alkenes, suggesting a novel synthetic pathway.

Key Points

  • This work aims to develop a new method for the direct conversion of amides into alkenes.
  • Utilized 9-borabicyclo[3.3.1]nonane (9-BBN) as the reductant.
  • Employed Cp2ZrCl2 as a precatalyst.
  • Conducted mechanistic investigations to understand the reaction pathway.
  • Successfully converted amides to alkenes under mild conditions.
  • Mechanistic studies indicate that 9-BBN facilitates tandem C─O and C─N cleavage.

Cite This Study

Shi et al. (2026) studied this question.

synapsesocial.com/papers/6a0ea188be05d6e3efb60477https://doi.org/10.1002/ange.4999077
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Catalytic Selective Deoxygenation and Deamination of Amides to Access Alkenes2026 · 1 citations
  2. 2Selective Deoxygenative Electroreduction of Amides2026 · 3 citations
  3. 3Accessing Aerial Transformation of Arylmethanamines into Amides Using a Redox-Active Aryl-Substituted BIAN-Based Catalyst2026
  4. 4Reductive amination of carbonyl C–C bonds enables formal nitrogen insertion2024 · 2 citations
  5. 5Additive- and catalyst-free deoxygenative reduction of amides and imides to amines with ammonia borane2025