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July 21, 2025BMC Pregnancy and ChildbirthOpen Access

Perioperative use of esketamine for the prevention of postpartum depression after cesarean section: a meta-analysis

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Authors

YLYanhong LiKZKuangyu ZhaoPCPeipei Cao

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Overview

Meta-analysis shows esketamine significantly reduces postpartum depression incidents and pain scores after cesarean section, indicating its efficacy as an analgesic.

Key Points

  • MAIN FINDING: Esketamine use during cesarean sections significantly reduces postpartum depression incidence (RR = 0.49).
  • KEY EVIDENCE: The Edinburgh Postnatal Depression Scale scores were also significantly lower in the esketamine group (SMD = -1.10).
  • APPROACH: The analysis included ten studies with a total of 1975 cases evaluating esketamine's effectiveness and safety.
  • SIGNIFICANCE: These findings support esketamine as a safe option for analgesia and prevention of early postpartum depression.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/689a060ee6551bb0af8cd3fahttps://doi.org/10.1186/s12884-025-07809-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effectiveness of ketamine on anxiety, irritability, and agitation: Implications for treating mixed features in adults with major depressive or bipolar disorder2020 · 65 citations
  2. 2Perioperative intravenous S(+)-ketamine for acute postoperative pain in adults: study protocol for a multicentre, randomised, open-label, positive-controlled, pragmatic clinical trial (SAFE-SK-A trial)2021 · 12 citations
  3. 3Effect of pre-administration of esketamine intraoperatively on postpartum depression after cesarean section: A randomized, double-blinded controlled trial2023 · 45 citations
  4. 4Esketamine in depression: putative biomarkers from clinical research2024 · 18 citations
  5. 5A Patient-Controlled Intravenous Analgesia With Tramadol Ameliorates Postpartum Depression in High-Risk Woman After Cesarean Section: A Randomized Controlled Trial2021 · 18 citations