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July 21, 2025BMC Medical EthicsOpen Access

Informed consent in genetic and genomic studies in Sub-Saharan Africa: a systematic review of bioethical issues

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Authors

YLYunqi LiUniversity of Southern CaliforniaDBDeborah J. BowenUniversity of WashingtonJYJoon‐Ho YuSeattle Pacific University

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Overview

Systematic review reveals informed consent challenges in genetic studies across Sub-Saharan Africa, highlighting bioethical issues and community engagement.

Key Points

  • Informed consent is crucial for protecting participant autonomy in genetic studies across Sub-Saharan Africa.
  • Twenty-four articles analyzed informed consent challenges, focusing on comprehension, voluntary participation, and community engagement.
  • Factors influencing comprehension include local culture, trust in the research team, and financial incentives for participation.
  • The review highlights the need for improved consent strategies to ensure ethical practices and participant welfare in genetics research.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/689a060ee6551bb0af8cd40ehttps://doi.org/10.1186/s12910-025-01170-z
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Also Consider

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  3. 3Understanding and processing informed consent during data-intensive health research in sub-Saharan Africa: challenges and opportunities from a multilingual perspective2024 · 1 citations
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  5. 5“It <i>just feels morally not right</i> to Sell the data”: Ethical and social perspectives on human genomic data sharing in Uganda—A phenomenological qualitative study2025 · 2 citations