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July 21, 2025

CSF1R regulates monocyte subset differentiation and intracellular metabolism.

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Authors

AGAlexandre GallerandJMJohanna MerlinZCZakariya Caillot

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Overview

Blockade of CSF1R impacts monocyte differentiation and metabolism, indicating its critical regulatory role.

Key Points

  • CSF1R blockade reduces differentiation of Ly6C high monocytes into Ly6C low monocytes.
  • Monocyte metabolic regulation is disrupted by acute CSF1R inhibition or genetic deletion.
  • The hexosamine biosynthetic pathway is a key regulator of CSF1R expression in monocytes.
  • Understanding CSF1R's role may advance therapeutic strategies for targeting inflammation and immunity.

Cite This Study

Gallerand et al. (2025) studied this question.

synapsesocial.com/papers/689a0614e6551bb0af8cd547https://doi.org/10.1101/2025.07.17.665275
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