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July 21, 2025Open Access

Activation of IL-17+ ILC subsets in IL-18R-deficient mice during fungal allergen exposure

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Authors

ASAllyssa StrohmBCBlake CivelloJBJana Badrani

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Overview

Knockout of IL-18R increases IL-17 and IL-5 in ILC2s, suggesting important roles in asthma pathology.

Key Points

  • ILC2s play a key role in asthma-related inflammation and produce critical cytokines.
  • Lack of IL-18 receptor leads to increased IL-17A and IL-5 production from ILC2s in response to fungal allergens.
  • Single-cell RNA sequencing revealed changes in IL-18 and IL-18R expression in ILCs after allergen exposure.
  • Understanding IL-18 signaling in ILCs may provide new targets for asthma treatments.

Cite This Study

Strohm et al. (2025) studied this question.

synapsesocial.com/papers/689a0614e6551bb0af8cd561https://doi.org/10.1101/2025.07.17.665289
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