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September 10, 2025AllergyOpen Access

The Expanding Role of ILC2s in Allergic Airways Disease

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Authors

JCJafar CainBHBenjamin P. HurrellOAOmid Akbari

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Overview

This review highlights ILC2s' significant contribution to allergic airways disease, suggesting novel therapeutic approaches.

Key Points

  • ILC2s are crucial in initiating and propagating allergic airways disease, impacting asthma management.
  • ILC2s produce key cytokines such as IL-5 and IL-13, driving the pathology of allergic asthma.
  • The review surveys current knowledge on ILC2 immunobiology, including their complex roles and activity modulation.
  • The findings may pave the way for new treatments targeting ILC2s in allergic airway diseases affecting millions.

Cite This Study

Cain et al. (2025) studied this question.

synapsesocial.com/papers/68c182589b7b07f3a060f2bfhttps://doi.org/10.1111/all.70030
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