July 21, 2025Open Access

Network Signatures of Disease Progression and Core Symptoms in Dementia with Lewy Bodies Distinct from Alzheimer's Disease

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Discussion

Functional connectivity differences in dementia with Lewy bodies and Alzheimer's disease indicate distinct disease progression patterns.

Dementia with Lewy bodies shows decreased connectivity in the salience and frontoparietal networks compared to controls.
Patients with dementia and mild cognitive impairment exhibited no significant differences in connectivity from Alzheimer's disease groups.
Results indicate that salience network connectivity correlates with clinical symptoms in dementia with Lewy bodies.
These findings suggest unique functional network impairments that could inform diagnosis and treatment strategies for dementia with Lewy bodies and Alzheimer's disease.

Gabriel et al. (2025) studied this question.

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