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July 22, 2025International Journal of Molecular SciencesOpen Access

Curcumin and Dementia: A Systematic Review of Its Effects on Oxidative Stress and Cognitive Outcomes in Animal Models

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Authors

SKSamuel Abiodun KehindeWLWai Phyo LinBLBo Bo Lay

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Overview

Systematic review shows curcumin reduces oxidative stress and improves cognitive outcomes in dementia models, indicating its potential as a neuroprotective agent.

Key Points

  • Curcumin demonstrated significant reductions in malondialdehyde, indicating decreased oxidative stress in dementia models.
  • Over 80% of studies reported improved cognitive outcomes, particularly in spatial learning and memory due to curcumin's effects.
  • A review of 29 preclinical studies utilized various rodent models of dementia to assess curcumin's neuroprotective effects.
  • Findings suggest curcumin's antioxidative and anti-inflammatory properties may offer new therapeutic avenues for neurodegenerative diseases.

Cite This Study

Kehinde et al. (2025) studied this question.

synapsesocial.com/papers/689a0614e6551bb0af8cd62ehttps://doi.org/10.3390/ijms26147026
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Curcumin and Neurocognitive Health: Mechanistic Insights and Translational Clinical Evidence2026
  2. 2The Neuroprotective Role of Curcumin: From Molecular Pathways to Clinical Translation—A Narrative Review2025 · 45 citations
  3. 3Investigating The Neuroprotective Role of Curcumin in Alzheimer's Disease Models2025 · 2 citations
  4. 4Neuroprotective and anti‐inflammatory effects of curcumin in Alzheimer's disease: Targeting neuroinflammation strategies2024 · 103 citations
  5. 5Curcumin in Alzheimer’s Disease: From Mechanistic Insights to Translational Challenges and Emerging Curcuminoid Strategies2026