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August 7, 2025Frontiers in Aging NeuroscienceOpen Access

Curcumin and neuroplasticity: epigenetic mechanisms underlying cognitive enhancement in aging and neurodegenerative disorders

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Authors

HJHao JiaoXWXiuying WangDZDongyu Zhang

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Overview

Review demonstrates curcumin's role in improving cognitive function in aging, suggesting it as a potential epigenetic agent for neurodegenerative disorders.

Key Points

  • Curcumin enhances neuroplasticity, which is critical for cognitive function in aging and neurodegenerative diseases.
  • It modulates epigenetic mechanisms such as DNA methylation and histone modifications to support cognitive resilience.
  • Curcumin influences neurogenesis and synaptic remodeling, which are essential for maintaining brain health.
  • Challenges remain in optimizing curcumin's bioavailability for effective therapeutic use in cognitive enhancement.

Cite This Study

Jiao et al. (2025) studied this question.

synapsesocial.com/papers/689dfe88d61984b91e13b8a7https://doi.org/10.3389/fnagi.2025.1592280
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